Developing novel antiepileptic drugs: Characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models
نویسندگان
چکیده
منابع مشابه
Antiepileptic Drugs and Mental Health Status of Patients with Epilepsy
Many patients with epilepsy suffer also from coexisting psychological problems. These mental co-morbidities have a significant impact on quality of life of patients with epilepsy. Recent studies have shown that although antiepileptic drugs (AEDs) treat epilepsy, they may increase risk of mental disorders in these patients . Due to the lack of adequate research in this area, we assess...
متن کاملTherapeutic monitoring of antiepileptic drugs for epilepsy.
BACKGROUND The aim of drug treatment for epilepsy is to prevent seizures without causing adverse effects. To achieve this, drug dosages need to be individualised. Measuring antiepileptic drug levels in body fluids (therapeutic drug monitoring) is frequently used to optimise drug dosage for individual patients. OBJECTIVES To review the evidence regarding the effects of therapeutic drug monitor...
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Background: Cicer arietinum (Chickpea) is one of the most important harvests in the world with high nutritional value. Lack of essential oils in the seeds of Chickpea is an advantage in search for drug-like molecules with less toxicity. We evaluated anticonvulsant effect of C. arietinum in common animal models of epilepsy. Methods: Dichloromethane extract was obtained from C. arietinum seeds by...
متن کاملAntiepileptic drugs and relapse after epilepsy surgery.
PURPOSE To evaluate whether the postoperative, antiepileptic drug (AED) regimen influences seizure recurrence after anterior temporal lobectomy when considering the putative mechanism of action and possible neuroprotective effects. METHODS This was a retrospective study. Patients who had an anterior temporal lobectomy for refractory epilepsy, whose preoperative MRI indicated mesial temporal s...
متن کاملAntiepileptic drugs: indications other than epilepsy.
Antiepileptic drugs (AEDs) are increasingly used for the treatment of several non-epileptic neurological conditions and psychiatric disorders. Most of the information available on the use of these agents in clinical disorders outside epilepsy is from case series, uncontrolled studies or small randomised clinical trials, and their apparent efficacy requires confirmation through well designed, la...
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ژورنال
عنوان ژورنال: Neurotherapeutics
سال: 2009
ISSN: 1933-7213,1878-7479
DOI: 10.1016/j.nurt.2009.01.001